Target intelligence / Profile preview

ADAM metallopeptidase domain 10

Molecular classification: Enzyme, Metalloprotease, Sheddase, Type I transmembrane protein

Overview

ADAM10 is a member of the ADAM (A Disintegrin And Metalloprotease) family and functions primarily as a sheddase, cleaving the ectodomains of membrane-bound proteins. It plays critical roles in cell signaling, neurogenesis, cell adhesion, and the nonamyloidogenic processing of APP, making it a therapeutic target for diseases like Alzheimer's and cancer. Its enzymatic activity can be modulated to treat these conditions.

Biological functions

Proteolytic cleavageCell adhesion regulationNeurogenesisEctodomain sheddingSignal transduction modulation

Disease associations

Alzheimer’s diseaseCancerAllergic reactionsReticulate Acropigmentation Of Kitamura

Beyond the preview

Go deeper on ADAM metallopeptidase domain 10.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on ADAM metallopeptidase domain 10.

Explore the full profile