ADAM metallopeptidase domain 20 pseudogene 3 (ADAM20P3)

ADAM metallopeptidase domain 20 pseudogene 3 (ADAM20P3) is classified as a pseudogene in the human genome, meaning it represents a DNA sequence closely related to the functional ADAM20 gene but is not itself capable of producing a functional protein product[1][3][4][5]. Pseudogenes are typically characterized by structural changes, such as premature stop codons, that disable their capacity for translation into active proteins[4][7]. ADAM20P3 is considered a close paralogue of ADAM20, part of the ADAM gene family, which encodes proteins generally involved in cell signaling, adhesion, and protease activity—but only when functional[4][6]. Because ADAM20P3 does not produce a functional protein, it is not considered a therapeutic target (i.e., not a receptor, enzyme, transporter, etc.), and there are no known drugs or disease associations relating to its activity[1][3][4][5]. The locus is located on chromosome 4: 188,667,248-188,669,353 on the reverse strand[3]. ADAM protein family pseudogenes like ADAM20P3 may be transcribed in certain tissues (notably testes), but lack protein-coding capacity and specific biological or disease functions[4][7]. Pseudogenes can sometimes have indirect roles, such as regulating related genes through non-coding RNA functions, but there is no reported evidence that ADAM20P3 has any such activity[1][3][4][5][7]. ADAM20P3 is a non-functional pseudogene of the ADAM family, with no biological activity, disease association, or drug interactions. It is not considered a therapeutic target, and its entry as a research target would be regarded as an error or misannotation.

Other names

disintegrin and metalloprotease domain protein pseudogeneADAM20P3

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