ADAM metallopeptidase domain 21 pseudogene 1 (ADAM21P1)

ADAM metallopeptidase domain 21 pseudogene 1 (ADAM21P1) is classified as a pseudogene, meaning it is a noncoding genomic sequence similar to the functional ADAM21 gene but lacks protein-coding potential due to mutations. Pseudogenes can exert regulatory effects at the RNA level, such as acting as decoys for microRNAs or binding regulatory proteins, but ADAM21P1 has no known protein product and is not considered a direct therapeutic target. The gene is found on chromosome 14q24.2. According to transcriptomic studies in head and neck cancer, ADAM21P1 is associated with patterns of cell adhesion and proliferation, but there is no evidence that it is actionable for drug targeting. No drugs, biomarkers, or known safety issues are linked to ADAM21P1, and its inclusion as a target would be erroneous in drug development contexts.

Other names

ADAM21Pa disintegrin and metalloproteinase domain 21 pseudogeneADAM21P1ADAM 21ADAM31