ADAM metallopeptidase domain 3A (ADAM3A)

ADAM metallopeptidase domain 3A (ADAM3A) belongs to the ADAM (a disintegrin and metalloproteinase) family, which typically have roles in cell adhesion, migration, proteolysis, and signaling[1][3]. However, ADAM3A is annotated as a pseudogene in humans and does not produce a functional protein[6]. Some other ADAM family members are important proteases involved in ectodomain shedding, reproductive biology (notably in rodents), and disease; however, these functions are not applicable to ADAM3A in humans. Reports regarding ADAM3A typically refer to data from non-human species (e.g., rodents or porcine studies) or are confounded by naming conventions; for example, in rats and pigs, ADAM3a may code for functional proteins involved in sperm-egg interactions[4][5], but this does not apply to humans. In short, ADAM3A is a pseudogene in humans, is not a therapeutic target, and does not have biological or clinical relevance[6]. Any disease associations, drug interactions, or molecular functions attributed to ADAM3A are misplaced, and care should be taken to avoid conflating this "target" with other functional ADAM family members.

Other names

ADAM3CYRN1TMDCIcyritestin 1a disintegrin and metalloproteinase domain 3A