ADAM metallopeptidase domain 5 (ADAM5)

ADAM metallopeptidase domain 5 (ADAM5) is a member of the ADAM (A Disintegrin And Metalloproteinase) family, which comprises transmembrane proteins with metalloprotease, disintegrin, cysteine-rich, and epidermal growth factor-like domains. However, in humans, ADAM5 exists only as a pseudogene (ADAM5P) and does not encode a functional, catalytically active protein. Thus, it does not contribute to known physiological or pathological processes in humans. Functional ADAM genes are important for cell-cell interactions, ectodomain shedding, and development, but these roles are carried out by other ADAM family members, such as ADAM10 and ADAM17, in humans. It is critical to distinguish the human ADAM5 (pseudogene) from its counterparts in other species, where it may have functional importance, particularly in reproductive biology in rodents.

Other names

ADAM5PTMDC2tMDCIIPutative disintegrin and metalloproteinase domain-containing protein 5Putative transmembrane metalloproteinase-like, disintegrin-like, and cysteine-rich protein IITMDCIIa disintegrin and metalloproteinase domain 5tMDC II