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Target intelligence / Profile preview
ADAM metallopeptidase domain 9 (ADAM9)
- Target
- ADAM9
- Molecular classification
- Metalloprotease, ADAM family member
01
Overview
ADAM metallopeptidase domain 9 (ADAM9) is a membrane-anchored protein and a member of the ADAM family of metalloproteases. It plays a role in cell-cell and cell-matrix interactions through its metalloprotease and disintegrin domains. It is involved in ectodomain shedding of various cell surface proteins, regulating signaling pathways. ADAM9 is implicated in cancer progression, retinal diseases and inflammation. It is upregulated by ROS and hydrogen peroxide.
02
Mechanism of action
Inhibition of metalloprotease activity to prevent ectodomain shedding and cell-cell/cell-matrix interactions.
03
Biological functions
ProteolysisEctodomain sheddingCell adhesionCell motilityTissue remodelingMatrix metalloproteinase synthesisRegulation of cellular motilityRegulation of signaling pathways
04
Disease associations
Cancer progression/metastasisRetinal diseasesInflammation
05
Safety considerations
Potential off-target effects due to broad substrate specificity of metalloproteases.Unintended consequences of inhibiting ectodomain shedding of various cell surface proteins.
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