ADAM metallopeptidase with thrombospondin type 1 motif 14 (ADAMTS14)

ADAM metallopeptidase with thrombospondin type 1 motif 14 (ADAMTS14) is a secreted extracellular matrix protease and a member of the ADAMTS family, characterized by a signal peptide, a prodomain, a metalloprotease domain, a disintegrin-like domain, and a thrombospondin-1-like domain. It functions mainly in the processing of the amino-propeptides of fibrillar collagens, enabling collagen fibril formation prior to collagen assembly in the extracellular matrix. ADAMTS14 plays roles in ECM remodeling, cell migration, angiogenesis, and inflammation. Pathologically, it is implicated in osteoarthritis (by contributing to cartilage degradation), intervertebral disc disease, cancer progression (tumor invasion and angiogenesis), cardiovascular remodeling, and neurodegenerative diseases (neuroinflammation and neuronal damage)

Other names

A disintegrin and metalloprotease with thrombospondin motifs 14ADAMTS14ADAM-TS14ADAMTS-14ATS14A disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 14

Inhibition or modulation of proteolytic activity for prevention of ECM degradation, tumor growth, or inflammation (inferred from disease roles and biological functions since no specific drug listed)