ADAM metallopeptidase with thrombospondin type 1 motif 20 (ADAMTS20)

ADAM metallopeptidase with thrombospondin type 1 motif 20 (ADAMTS20) is a member of the secreted ADAMTS family of zinc-dependent metalloproteases characterized by their modular structure, including multiple thrombospondin type 1 repeats. ADAMTS20 is primarily found in the extracellular matrix, where it participates in tissue remodeling by cleaving proteoglycans such as versican, contributing to processes like regression of interdigital webs and organogenesis. Recent findings also indicate a non-canonical role in ciliogenesis, where ADAMTS20, together with ADAMTS9, is involved in primary cilium formation and maintenance in specific cell types, likely impacting signaling pathways like Hedgehog. Mutations or inactivation in model organisms result in various developmental anomalies. No direct drug interactions, biomarker roles, or mechanisms of action in therapeutics have been established, but its functions suggest it may have future implications as a therapeutic target in fibrotic, developmental, or matrix-associated diseases[1][2][3][4][5].

Other names

ADAMTS-20ADAM-TS20GON-1ADAMTS20ADAM-TS 20a disintegrin and metalloproteinase with thrombospondin motifs 20