ADAMTS-like protein 4 (ADAMTSL4)

ADAMTS-like protein 4 is a secreted glycoprotein encoded by the ADAMTSL4 gene in humans. It is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs)-like gene family and is structurally distinct from enzymatically active ADAMTS proteases in that it lacks a catalytic domain. ADAMTSL4 contains seven thrombospondin type 1 repeats, domains found in proteins that regulate diverse biological processes such as cellular adhesion, angiogenesis, and developmental patterning of the nervous system. Mutations in ADAMTSL4 are associated with disorders such as isolated ectopia lentis, characterized by displacement of the eye lens[1][2]. ADAMTS-like proteins do not have demonstrated enzymatic activity and are primarily implicated in the formation and maintenance of the extracellular matrix rather than serving as direct drug targets or therapeutic receptors[1][2][3].

Other names

ADAMTSL4ADAMTS like 4