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ADAMTSL4 antisense RNA 1 (ADAMTSL4-AS1) is a long non-coding RNA (lncRNA) gene located on human chromosome 1, often described by its previous designation C1orf138[1][7]. It does not encode a receptor or enzyme but belongs to the molecular class of lncRNAs, which are typically involved in gene regulation rather than direct coding of functional proteins[7]. ADAMTSL4-AS1 is considered uncharacterized, as current research has not conclusively determined its specific biological functions, cellular roles, or direct involvement in disease processes[2][7]. There are no known drugs or therapeutic agents directly targeting this RNA, nor is it established as a biomarker or therapeutic target. It is distinct from ADAMTSL4, a protein-coding gene involved in extracellular matrix assembly; ADAMTSL4-AS1 is its antisense RNA and may regulate, but is not itself a protein or therapeutic target[1][7].
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