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Target intelligence / Profile preview
Adapter Associated Kinase 1 (AAK1)
- Target
- AAK1
- Molecular classification
- Enzyme, Serine/threonine kinase, Prk/Ark family of serine/threonine kinases
01
Overview
AAK1 functions as a master regulator within the machinery controlling receptor internalization through clathrin-coated vesicles. Its pivotal roles span from basic neuronal function to broader implications across several diseases—including chronic pain syndromes—making it an active focus for drug discovery efforts targeting both neurological disorders and viral infections.
- Other names
- AP2 associated kinase 1AP2-associated protein kinase 1
02
Mechanism of action
Small molecule inhibition of AAK1 kinase activity, preventing phosphorylation of AP-2 and disrupting clathrin-mediated endocytosis.
03
Biological functions
Ser/Thr phosphorylationRegulation of clathrin-mediated endocytosisReceptor internalizationSynaptic vesicle recyclingRegulation of Notch signaling
04
Disease associations
Neuropathic painAlzheimer's diseaseParkinson's syndromeViral invasion
05
Interacting drugs
LX9211/BMS‑986176
2 more in the full profile.
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