Adaptive immune receptors recognizing Shigella flexneri 2a antigens (SF2a-AIRs)

Adaptive immune receptors recognizing Shigella flexneri 2a antigens refer to the diverse repertoire of B-cell receptors (BCRs) and T-cell receptors (TCRs) specifically evolved or selected to bind antigens from the Shigella flexneri 2a serotype. These receptors are central to the host's adaptive immune defense against shigellosis, a leading cause of bacterial dysentery worldwide. The primary targets for these receptors include the O-specific polysaccharide (O-SP) of the lipopolysaccharide (LPS) and various virulence-associated proteins such as the Invasion Plasmid Antigens (IpaB, IpaC, IpaD). In a therapeutic context, these receptors are not targets for inhibition but are the intended effectors of vaccine-induced immunity. Vaccines, such as synthetic carbohydrate conjugates or live-attenuated strains, interact with these receptors to stimulate the production of protective antibodies and cell-mediated immunity. Understanding the structural basis of how these receptors recognize S. flexneri 2a antigens is critical for the design of next-generation vaccines and monoclonal antibody therapies aimed at providing serotype-specific protection.

Other names

Shigella flexneri 2a-specific B-cell receptorsShigella flexneri 2a-specific T-cell receptorsAnti-Shigella flexneri 2a antibodiesS. flexneri 2a-specific BCRsS. flexneri 2a-specific TCRs

Vaccines containing Shigella flexneri 2a antigens (such as O-antigen or Ipa proteins) bind to these adaptive immune receptors on B-cells and T-cells to trigger clonal expansion, affinity maturation, and the generation of protective memory cells and neutralizing antibodies.