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Target intelligence / Profile preview
Adaptor-associated kinase 1 (AAK1)
- Target
- AAK1
- Molecular classification
- Enzyme, Ser/Thr protein kinase
01
Overview
Adaptor-associated kinase 1 (AAK1) is a serine/threonine protein kinase that regulates clathrin-mediated endocytosis by phosphorylating subunits of the AP-2 complex. It is involved in various physiological processes and diseases, including neuropathic pain, neurodegenerative diseases, and viral infections. Several small molecule inhibitors targeting AAK1 are under development.
- Other names
- AP2-associated protein kinase 1AP2 associated kinase 1
02
Mechanism of action
Inhibition of AAK1 kinase activity, modulation of AP-2 phosphorylation.
03
Biological functions
Regulation of clathrin-mediated endocytosisReceptor traffickingSynaptic vesicle recycling
04
Disease associations
Neuropathic painAlzheimer’s diseaseParkinson’s syndromeViral infections
05
Safety considerations
Potential off-target effects on general endocytic processesSelectivity remains an important consideration
06
Interacting drugs
BMS‑986176/LX‑9211
2 more in the full profile.
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