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Adaptor protein complex 1 subunit beta-1 (AP1B1)
- Target
- AP1B1
- Molecular classification
- Adaptin protein family, Vesicular trafficking complex, Clathrin adaptor complex component, Other
01
Overview
AP1B1 encodes the beta-1 subunit of adaptor protein complex 1 (AP-1), a component of clathrin-coated vesicles primarily localized at the cytoplasmic face of the Golgi complex. The AP-1 complex functions in the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic domains of transmembrane proteins, thereby mediating protein sorting in intracellular trafficking pathways. It is a structural protein, not a receptor or enzyme, and is essential for normal cell physiology. Mutations or defects are associated with meningioma, as well as certain syndromic disorders affecting the skin, eyes, and hearing. The complex is a heterotetramer, and AP1B1 is one of its large subunits.
- Other names
- ADTB1AP105ABAM22CLAPB2Adaptor protein complex AP-1 subunit beta-1Adaptor-related protein complex 1 subunit beta-1Beta-1-adaptinBeta-adaptin 1Clathrin assembly protein complex 1 beta large chainGolgi adaptor HA1/AP1 adaptin beta subunitbeta-prime-adaptinKIDARadapter-related protein complex 1 subunit beta-1
02
Biological functions
Protein sorting in the Golgi/trans-Golgi networkRecognition of sorting signals in cytosolic tails of transmembrane receptorsRecruitment of clathrin to membranesIntracellular vesicle trafficking
03
Disease associations
Meningioma (candidate gene)Keratitis-ichthyosis-deafness syndromeIchthyosiform erythroderma, corneal involvement, and hearing loss
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