Adaptor-related protein complex 1-associated regulatory protein (AP1AR)

Adaptor-related protein complex 1-associated regulatory protein (AP1AR) is a cytosolic protein that plays a key role in adaptor protein complex 1 (AP-1)-dependent trafficking between the trans-Golgi network and endosomes. It regulates the association of the AP-1 complex with membranes and links AP-1-mediated membrane traffic to kinesin-based microtubular transport, thus coordinating intracellular vesicular transport. AP1AR can inhibit the Arp2/3 complex, affecting cell spreading and motility. It does not have a clear role as a traditional therapeutic target such as a receptor, enzyme, transporter, or ion channel, and there are no well-described small molecules or drugs known to directly interact with it[1][5]. Key Points: - The canonical full name is "Adaptor-related protein complex 1-associated regulatory protein" and the established abbreviation is AP1AR[1][5]. - This protein is not generally considered a traditional therapeutic target such as a receptor, enzyme, transporter, or ion channel[1][5]. - Its main known function is in regulating vesicle trafficking, AP-1 complex-membrane association, and microtubular transport through kinesin interaction[1][5]. - It goes by multiple aliases, including Gadkin and GBAR[1]. - There are currently no approved drugs or mechanisms of action targeting this protein, nor specific disease roles, safety concerns, or biomarker functions established in the mainstream literature[1][5].

Other names

GadkinGBARGamma-BARGamma1-adaptin brefeldin A resistance proteinGamma1-adaptin brefeldin A resistanceChromosome 4 open reading frame 162c18C4orf16AP-1 complex-associated regulatory proteinAdapter-related protein complex 1-associated regulatory protein