Adaptor related protein complex 1 subunit sigma 2 (AP1S2)

Adaptor related protein complex 1 subunit sigma 2 (AP1S2) encodes the small sigma-2 subunit of the clathrin-associated adaptor protein complex 1 (AP-1). The AP-1 complex regulates vesicle formation and protein sorting at the trans-Golgi network and endosomes by recognizing sorting signals in transmembrane proteins and recruiting clathrin to the membrane surface[1][3]. It is essential for proper cell function, particularly in neurons, and disruption of its function via mutation can cause syndromic X-linked mental retardation and related neurodevelopmental disorders such as Pettigrew syndrome[1][2][7]. AP1S2 is not considered a classical therapeutic target but is implicated in the molecular machinery that governs protein sorting and vesicular trafficking in human cells.

Other names

AP-1 complex subunit sigma-2AP1S2SIGMA1BSigma1B-adaptinAdaptor-related protein complex 1 subunit sigma-1BClathrin assembly protein complex 1 sigma-1B small chainGolgi adaptor HA1/AP1 adaptin sigma-1B subunitDC22MRX59MRXS21MRXS5MRXSFPGSSigma 1B subunit of AP-1 clathrinAdapter-related protein complex 1 sigma-1B subunitMental Retardation, X-Linked 59Pettigrew X-Linked Mental Retardation Syndrome

Null. No established drugs target AP1S2 directly.