Adaptor-related protein complex 5 subunit mu-1 (AP5M1)

Adaptor-related protein complex 5 subunit mu-1 (AP5M1) is the medium subunit of the AP-5 adaptor protein complex, a putative fifth member of the AP complexes involved in vesicular trafficking, especially endosomal transport. AP5M1 (also known as MUDENG or MuD) is expressed throughout the body, localizing to the cytosol, late endosome, lysosome, mitochondria, and endoplasmic reticulum. It regulates the expression of the pro-apoptotic protein BAX and can induce cell death in tumor cells, particularly via mechanisms linked to Fas-mediated and TRAIL-mediated apoptosis. AP5M1 features a conserved adaptin domain with caspase-3 binding sites, which allows it to modulate apoptosis, possibly providing an anti-apoptotic effect in the context of TRAIL signaling by sequestering caspase-3 away from crucial substrates such as BID. There is no current evidence that AP5M1 is a direct therapeutic target for any drugs.

Other names

MuDMUDENGMu5C14orf108FLJ10813Mu-2-related death-inducing proteinPutative HIV-1 infection-related proteinMu-2 related death-inducing geneMU-2/AP1M2 domain containing, death-inducingMHD domain-containing death-inducing proteinAdapter-related protein complex 5 mu subunitAdapter-related protein complex 5 subunit mu-1AP-5 complex subunit muChromosome 14 open reading frame 108Adaptor-related protein complex 5 mu 1 subunitMu-2 related death-inducingAdapter-related protein complex 5 subunit mu 1