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Adaptor-related protein complex 5 subunit zeta-1 (AP5Z1)
- Target
- AP5Z1
- Molecular classification
- Other, Intracellular trafficking protein (Adaptor protein complex component)
01
Overview
Adaptor-related protein complex 5 subunit zeta-1 (AP5Z1) is a large subunit of the AP-5 adaptor protein complex, which mediates intracellular protein traffic, particularly a sorting step from late endosomes to the Golgi apparatus. AP5Z1 is implicated in endosomal transport, lysosomal homeostasis, and efficient homologous recombination-mediated DNA repair. Damaging variants in AP5Z1 are causative for SPG48, a complicated form of hereditary spastic paraplegia characterized by progressive neurodegeneration and aberrant endolysosomes. AP5Z1 is not generally considered a classical therapeutic target such as a receptor or enzyme, and no drugs are currently known to specifically target this protein[1][2][3][4].
- Other names
- AP5Z1KIAA0415SPG48zetaAdaptor-related protein complex 5 zeta subunitadaptor related protein complex 5 subunit zeta 1adaptor related protein complex 5 zeta 1 subunitzeta5AP-5 complex subunit zeta-1AP5Z1_HUMAN
02
Biological functions
Endosomal transportProtein sortingHomologous recombination DNA repairLysosomal homeostasis
03
Disease associations
Neurodegenerative diseaseHereditary spastic paraplegia (specifically SPG48)
04
Safety considerations
Potential for neurodegeneration (mutations linked to hereditary spastic paraplegia)
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