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ADD3 antisense RNA 1 (ADD3-AS1)
- Target
- ADD3-AS1
- Molecular classification
- Long non-coding RNA (lncRNA), Antisense RNA transcript
01
Overview
ADD3 antisense RNA 1 (ADD3-AS1) is a long non-coding RNA located on human chromosome 10 that functions mainly as an antisense transcript regulating the protein-coding gene ADD3 (adducin 3)[5][3]. It is implicated in the control of cellular processes such as proliferation, apoptosis, migration, and inflammation[1][2]. Altered ADD3-AS1 levels have been linked to liver fibrosis, especially in the context of biliary atresia, as well as to several cancers, cardiovascular, neurological, and inflammatory diseases[1][2][7]. Its regulatory function occurs via gene expression modulation, often affecting ADD3 and related molecular pathways. ADD3-AS1 is considered a potential biomarker for specific disease states, notably liver fibrosis in infants with biliary atresia[1][7]. There are no known drug interactions or direct therapies targeting ADD3-AS1.
- Other names
- ADD3-AS1adducin 3 antisense RNA 1lnc-ADD3-AS1ADD3 antisense long non-coding RNA 1
02
Biological functions
Regulation of gene expression (especially via antisense effects on ADD3)Regulation of cell proliferationRegulation of cell migrationRegulation of apoptosisInflammation/immune response modulation
03
Disease associations
Liver fibrosis, especially in biliary atresiaCancer, including lung, colorectal, and gastric cancerCardiovascular disease (role in hypertrophy/angiogenesis)Neurological disorders (Alzheimer’s, Parkinson’s)Inflammatory and autoimmune disorders
04
Biomarkers
Potential diagnostic or prognostic biomarker for liver fibrosis in biliary atresia
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