Additional kinases

The term Additional kinases refers to a non-specific group of enzymes within the phosphotransferase family that catalyze the transfer of phosphate groups from high-energy molecules to specific substrates. This designation is typically used in pharmacological profiling to describe the secondary or off-target kinase inhibition exhibited by multi-kinase inhibitors beyond their primary intended targets. Because the human kinome comprises over 500 distinct kinases that regulate nearly every aspect of cellular physiology, including growth, differentiation, and metabolism, the modulation of additional kinases can significantly impact drug safety and efficacy. In many clinical contexts, the inhibition of these non-specific kinases is associated with increased systemic toxicity and adverse events due to the disruption of essential homeostatic signaling pathways. Consequently, Additional kinases does not represent a single, well-defined therapeutic target but rather a collective category of enzymes that complicates the development of highly selective small-molecule inhibitors.

Other names

Other kinasesOff-target kinasesSecondary kinases

Inhibition of phosphate group transfer from ATP to substrate proteins