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Target intelligence / Profile preview
Adenine nucleotide translocase (ANT)
- Target
- ANT
- Molecular classification
- Transporter, Mitochondrial carrier family, Solute Carrier Family SLC25
01
Overview
Adenine nucleotide translocase (ANT) is a mitochondrial inner membrane protein responsible for exchanging ATP and ADP between the mitochondrial matrix and the cytoplasm. It plays a crucial role in cellular energy metabolism and is implicated in apoptosis and cancer metabolism. There are four main isoforms (ANT1-4) with distinct tissue-specific expression patterns.
- Other names
- ADP/ATP translocaseMitochondrial ADP/ATP carrier proteinSLC25A4SLC25A5SLC25A6SLC25A31
02
Mechanism of action
Inhibits ATP/ADP exchange; modulates mPTP opening
03
Biological functions
Exchange of ATP and ADPCellular energy metabolismRegulation of apoptosisRegulation of mitochondrial permeability transition pore (mPTP)
04
Disease associations
Mitochondrial diseasesCancerNeurodegenerative diseasesCardiomyopathy
05
Safety considerations
Potential for disrupting cellular energy homeostasisInduction of apoptosisInteraction with mPTP and associated cell death pathways
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