Molecular Classification
Transporter, Mitochondrial carrier family
Other Names
AAC1, ADP/ATP carrier protein 1, ADT1_HUMAN, ANT, ANT 1, Heart/skeletal muscle ATP/ADP translocator
Disease Roles
ApoptosisCancerCell death

Adenine Nucleotide Translocase 1 Overview

Adenine nucleotide translocase 1 (ANT1) is a mitochondrial inner membrane protein that mediates the exchange of ADP and ATP across the inner mitochondrial membrane, playing a central role in cellular energy metabolism. It is implicated in apoptosis, cancer, and necrotic cell death pathways.

Mechanism of Action

Inhibition of ADP/ATP exchange

Biological Functions

ADP/ATP exchange
Oxidative phosphorylation
Modulation of proton leak

Disease Associations

Apoptosis
Cancer
Cell death

Safety Considerations

  • Role in mitochondrial permeability transition pore (mPTP) opening
  • Implicated in apoptosis and necrotic cell death pathways
  • Potential for drug resistance in cancer

Interacting Drugs

Bongkrekic acid
Carboxyatractyloside