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Target intelligence / Profile preview
Adenine Nucleotide Translocase 1 (ANT1)
- Target
- ANT1
- Molecular classification
- Transporter, Mitochondrial carrier family
01
Overview
Adenine nucleotide translocase 1 (ANT1) is a mitochondrial inner membrane protein that mediates the exchange of ADP and ATP across the inner mitochondrial membrane, playing a central role in cellular energy metabolism. It is implicated in apoptosis, cancer, and necrotic cell death pathways.
- Other names
- AAC1ADP/ATP carrier protein 1ADT1_HUMANANTANT 1Heart/skeletal muscle ATP/ADP translocator
02
Mechanism of action
Inhibition of ADP/ATP exchange
03
Biological functions
ADP/ATP exchangeOxidative phosphorylationModulation of proton leak
04
Disease associations
ApoptosisCancerCell death
05
Safety considerations
Role in mitochondrial permeability transition pore (mPTP) openingImplicated in apoptosis and necrotic cell death pathwaysPotential for drug resistance in cancer
06
Interacting drugs
Bongkrekic acid
1 more in the full profile.
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