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Adenine phosphoribosyltransferase (None)
- Target
- None
- Molecular classification
- Enzyme, Phosphoribosyltransferase, Type I PRTase family
01
Overview
Adenine phosphoribosyltransferase (APRT) is an enzyme that plays a crucial role in the purine salvage pathway, which recycles purines to maintain nucleotide pools and cellular energy balance. It catalyzes the conversion of adenine and 5-phosphoribosyl-1-pyrophosphate (PRPP) into adenosine monophosphate (AMP) and pyrophosphate. Deficiency in APRT activity causes adenine phosphoribosyltransferase deficiency, an autosomal recessive disorder characterized by recurrent kidney stones and risk for renal failure. APRT is a promising drug target for antiparasitic therapies since inhibition could selectively affect pathogen viability without harming host cells.
02
Mechanism of action
Inhibition of APRT activity, particularly in protozoan parasites
03
Biological functions
Purine salvageNucleotide biosynthesisMaintenance of nucleotide poolsCellular energy balance
04
Disease associations
Adenine phosphoribosyltransferase deficiencyKidney stonesRenal failureEnd-stage renal disease (ESRD)
05
Safety considerations
Potential for toxicity in humans due to central metabolic role if broadly inhibited.Care is required in humans and other mammals due to its central metabolic role
06
Interacting drugs
Allopurinol
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