Adeno-associated virus capsid displaying cell-surface marker-specific designed ankyrin repeat protein domain (null)

This target refers to a **synthetic viral vector system** in which the capsid of an adeno-associated virus (AAV) is genetically or chemically modified to present a **designed ankyrin repeat protein (DARPin) domain** on its surface. DARPins are engineered protein scaffolds that can bind specific cell-surface markers with high affinity. By displaying a chosen DARPin on the AAV capsid, the virus acquires targeted binding to cells displaying the cognate marker, enabling **cell-specific gene delivery**. The underlying AAV capsid is composed of 60 copies of viral proteins VP1, VP2, and VP3, which form an icosahedral structure and mediate the virus's natural cell entry[1][2][4][5][6]. Attachment of a DARPin redirects this natural specificity to user-chosen targets (e.g., disease-associated antigens), improving therapeutic index in gene therapy applications. Such constructs are experimental platforms in gene/cell therapy research and are not recognized as canonical endogenous therapeutic targets or receptors.

Other names

AAV capsid with DARPin displayDARPin-AAV capsidCell-targeted AAV (with ankyrin repeat domain)Engineered AAV capsid for cell-specific binding

Redirected cell entry: The DARPin domain binds a chosen cell-surface marker, redirecting AAV tropism and enhancing selective uptake. Cell-specific transduction: AAV delivers its genetic payload preferentially to marker-positive cells.