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Target intelligence / Profile preview
Adenomatous Polyposis Coli (APC)
- Target
- APC
- Molecular classification
- Tumor Suppressor, Wnt signaling regulator, Other
01
Overview
The adenomatous polyposis coli protein serves as an essential tumor suppressor at both molecular signaling levels—primarily via negative regulation of Wnt/β-catenin—and broader cellular architecture maintenance. Its dysfunction underlies inherited syndromes like FAP as well as most sporadic cases of colon cancer through loss-of-function mutations disrupting these pathways.
- Other names
- DP2.5Deleted in polyposis 2.5
02
Mechanism of action
Wnt pathway modulation; induction of β-catenin degradation
03
Biological functions
Tumor suppressionNegative regulator of Wnt/β-catenin pathwayCell cycle controlCytoskeleton organizationCell adhesionCell migrationRegulation of gene expressionImmune response
04
Disease associations
Familial adenomatous polyposis (FAP)Colorectal cancerCancer
05
Safety considerations
Potential for off-target effects in Wnt signalingComplex role in multiple cellular processes
06
Biomarkers
APC mutations in tumor tissueAPC mutations in germline DNA
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