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Target intelligence / Profile preview
Adenosine A₂A Receptor (ADORA2A)
- Target
- ADORA2A
- Molecular classification
- G protein-coupled receptor
01
Overview
The adenosine A₂A receptor (ADORA2A) is a G protein-coupled receptor that primarily mediates its effects through activation of stimulatory G proteins (Gs), leading to increased intracellular cAMP levels. It is expressed widely in the brain—especially in striatum—and also found in immune cells such as CD8+ T cells and mast cells. It plays roles in neurotransmitter release, motor control, cardiac function modulation, and immunomodulation, making it a therapeutic target for Parkinson's disease and cancer immunotherapy.
- Other names
- A2A receptorAdenosine receptor A2A
02
Mechanism of action
A₂A receptor agonists or antagonists modulate cAMP production via Gs protein signaling
03
Biological functions
Neurotransmission modulationCardiac regulationImmunomodulationSignal transductionRegulation of T cell activity
04
Disease associations
Parkinson’s diseaseCancerNeurodegenerative disease
05
Interacting drugs
Preladenant
1 more in the full profile.
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