Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Adenosine A1 Receptor (A1AR)
- Target
- A1AR
- Molecular classification
- G protein-coupled receptor
01
Overview
The adenosine A1 receptor (A1AR) is a G protein-coupled receptor that binds adenosine. It is widely expressed, particularly in the central nervous system and cardiovascular system, where it mediates a variety of physiological effects including neuromodulation, cardioprotection, and regulation of sleep. A1AR activation generally has an inhibitory effect on cellular activity. Dysregulation of A1AR is implicated in various diseases, and selective ligands are under development for therapeutic applications.
- Other names
- RDC7adenosine receptor A1A1RA₁R
02
Mechanism of action
Agonists: Activation of Gi/o proteins, inhibition of adenylate cyclase, activation of potassium channels, inhibition of calcium channels. Antagonists: Blockade of adenosine binding and downstream signaling.
03
Biological functions
Signal transductionNeuromodulationNeuroprotectionCardioprotectionRegulation of heart rateRegulation of vascular tensionInhibition of neurotransmitter releaseSleep promotion
04
Disease associations
Cardiovascular diseaseNeurodegenerative diseaseSleep disordersPainIschemia-reperfusion injury
05
Safety considerations
Potential cardiovascular effects (bradycardia, hypotension)CNS effects (sedation, dizziness)Off-target effects due to adenosine's widespread actions
Beyond the preview
Go deeper on Adenosine A1 Receptor (A1AR).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Adenosine A1 Receptor (A1AR).