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Target intelligence / Profile preview
Adenosine A2B Receptor (ADORA2B)
- Target
- ADORA2B
- Molecular classification
- G protein-coupled receptor, Receptor
01
Overview
The adenosine A2B receptor (ADORA2B) is a G protein-coupled receptor that binds adenosine. It is involved in various physiological processes, including regulation of vascular tone and modulation of immune responses. A2BR signaling has been implicated in diseases such as cancer, renal disease, diabetes, vascular disease, and lung disease. Blockade of the A2BR enhances lymphocyte proliferation and function, suggesting therapeutic potential for overcoming immune suppression by tumors.
- Other names
- A2BR
02
Mechanism of action
Agonists stimulate adenylate cyclase activity, increasing intracellular cAMP levels. Antagonists block adenosine binding and downstream signaling.
03
Biological functions
Signal transductionRegulation of vascular toneModulation of immune responsesAdenylate cyclase/cAMP production
04
Disease associations
CancerRenal diseaseDiabetesVascular diseaseLung diseaseTumor microenvironment modulation
05
Interacting drugs
BAY 60-6583
17 more in the full profile.
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