Adenosine A2b receptor pseudogene 1 (ADORA2BP1)

Adenosine A2b receptor pseudogene 1 (ADORA2BP1) is a non-functional genomic sequence that closely resembles the A2b adenosine receptor gene but cannot encode a functional receptor protein. Its sequence shares high identity (about 79%) with the coding sequence of the real adenosine A2b receptor gene (ADORA2B), but it is unable to produce an active receptor due to accumulated mutations or deletions[2][6][10][1][8]. The functional adenosine A2b receptor (ADORA2B), not the pseudogene, mediates physiological responses through G protein-coupled signaling and is a validated therapeutic target in fields such as inflammation, vascular physiology, and cancer[5][7][9]; ADORA2BP1 plays no direct role in these processes. In summary: ADORA2BP1 (Adenosine A2b receptor pseudogene 1) is a pseudogene, not a receptor; it is neither a therapeutic target nor relevant for drug development or disease roles, and is often incorrectly cited as a target due to confusion with the functional adenosine A2b receptor (ADORA2B)[1][2][6][8][10].

Other names

ADORA2BPAdenosine A2b receptor pseudogene