Adenosine Deaminase (ADA)

Adenosine deaminase (ADA) is an enzyme crucial for purine metabolism, catalyzing the irreversible deamination of adenosine and deoxyadenosine to inosine and deoxyinosine, respectively. It plays a key role in maintaining adenosine homeostasis and modulating immune responses. ADA deficiency leads to severe combined immunodeficiency disease (SCID), while elevated levels can be a diagnostic marker for diseases like tuberculosis. Inhibitors targeting this enzyme have therapeutic potential in immunosuppression, cancer therapy, and other applications.

Other names

Adenosine aminohydrolase

Inhibition of adenosine deamination, leading to increased adenosine/deoxyadenosine levels or modulation of immune cell interactions.