Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Adenosine Deaminase Acting on RNA 1 p150 Isoform (ADAR1 p150)
- Target
- ADAR1 p150
- Molecular classification
- Enzyme, RNA-binding protein, Deaminase
01
Overview
The human Adenosine Deaminase Acting on RNA 1 (ADAR1) p150 isoform is an IFN-inducible enzyme primarily responsible for broad-spectrum adenosine-to-inosine editing events within cellular RNAs—especially those found in double-stranded conformations—and plays essential roles both in regulating innate immunity through suppression of aberrant MDA5 activation and maintaining normal physiological processes such as embryonic development and adaptive immune responses. Its dysfunction underlies several genetic disorders involving pigmentation or autoinflammation due to improper handling or sensing of endogenous nucleic acids.
- Other names
- ADAR1 isoform 2ADAR1 Long isoformADAR1 Interferon-inducible isoformp150 ADAR1
02
Mechanism of action
A-to-I RNA editing; regulation of innate immune sensors
03
Biological functions
A-to-I RNA editingInnate immune regulationRegulation of MDA5 activationRNA modification
04
Disease associations
Dyschromatosis symmetrica hereditariaAicardi-Goutières syndromeAutoinflammatory diseases
05
Safety considerations
Potential for off-target RNA editingDisruption of normal RNA processingAutoimmunity if editing is dysregulated
Beyond the preview
Go deeper on Adenosine Deaminase Acting on RNA 1 p150 Isoform (ADAR1 p150).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Adenosine Deaminase Acting on RNA 1 p150 Isoform (ADAR1 p150).