Target intelligence / Profile preview

Adenosine Diphosphate (ADP)

Target
ADP
Molecular classification
Nucleotide, Metabolite
01

Overview

Adenosine diphosphate is an essential nucleotide involved primarily in cellular energy transfer via its interconversion with ATP. Its structure comprises adenine linked to ribose plus two phosphates; it functions centrally both metabolically—in processes like glycolysis—and physiologically—in platelet activation through specific purinergic receptors.

Other names
Adenosine-diphosphateADP(3−)Adenosine pyrophosphateAdenosine–5′–diphosphate[(2R,3S,4R,5R)-5-(6-Aminopurin‑9‑yl)-3,4-dihydroxyoxolan‑2‑yl]methoxy‑oxidophosphoryl] phosphate
02

Mechanism of action

ADP interacts with P2Y1 and P2Y12 receptors on platelets, promoting platelet aggregation and blood clotting. Antiplatelet drugs block these receptors.

03

Biological functions

Energy transferPlatelet activationSubstrate-level phosphorylationOxidative phosphorylationPhotophosphorylationMetabolic intermediate
04

Disease associations

Thrombosis
05

Interacting drugs

P2Y12 receptor antagonists (e.g., Clopidogrel, Prasugrel, Ticagrelor)

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