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Adenosine Equilibrative Transporter (ENT)
- Target
- ENT
- Molecular classification
- Transporter, Membrane protein
01
Overview
Adenosine Equilibrative Transporters (ENTs) are a family of membrane proteins that mediate the bidirectional transport of adenosine and other nucleosides across cell membranes. They play a crucial role in regulating extracellular and intracellular adenosine levels, influencing purinergic signaling, energy metabolism, and nucleic acid synthesis. ENTs are targets for adenosine reuptake inhibitors and mediate the cellular entry of nucleoside analog drugs.
- Other names
- Equilibrative Nucleoside TransporterSLC29 familyhENT1hENT2hENT3hENT4
02
Mechanism of action
Bidirectional/passive transport of nucleosides based on concentration gradients; inhibition of adenosine reuptake
03
Biological functions
Nucleoside transportAdenosine regulationPurinergic signaling modulationDNA/RNA synthesisCellular uptake of nucleosides
04
Disease associations
Cardiovascular diseaseCancerViral infections
05
Interacting drugs
Dipyridamole
4 more in the full profile.
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