Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Adenosine Kinase (ADK)
- Target
- ADK
- Molecular classification
- Enzyme, Kinase, Phosphofructokinase B (PfkB) family, Sugar kinase
01
Overview
Adenosine kinase (ADK) is a highly conserved enzyme that regulates intracellular and extracellular adenosine concentrations by catalyzing the phosphorylation of adenosine to adenosine monophosphate (AMP). It plays a crucial role in adenine nucleotide homeostasis and modulating adenosine receptor-mediated signaling. ADK dysregulation is implicated in diseases like hypermethioninemia and epilepsy, and it is explored as a potential therapeutic target for diabetes, cancer, and inflammation.
02
Mechanism of action
ADK inhibitors increase local or systemic adenosine concentrations.
03
Biological functions
Adenosine metabolismRegulation of adenosine levelsPurinergic signaling modulationAdenine nucleotide homeostasisEpigenetic regulation (long isoform)Methylation reactions
04
Disease associations
HypermethioninemiaEpilepsyDiabetes (potential)Cancer (potential)Inflammation (potential)
05
Safety considerations
Potential side effects related to increased adenosine levels (e.g., cardiovascular effects)Challenges in achieving tissue-specific inhibition
06
Biomarkers
Neuropathological marker in epileptic brain tissue
Beyond the preview
Go deeper on Adenosine Kinase (ADK).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Adenosine Kinase (ADK).