Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Adenosine Metabolic Pathway (AMP)
- Target
- AMP
- Molecular classification
- Metabolic pathway, Enzyme cascade, Signaling cascade
01
Overview
The adenosine metabolic pathway encompasses the synthesis, breakdown, and signaling functions of adenosine. It is a crucial target for drug development, especially with adenosine analogs, aimed at modulating immune responses and cellular metabolism by targeting enzymes such as CD39, CD73, ADA, and PNP, as well as adenosine receptors A1, A2A, A2B, and A3.
- Other names
- Adenosine PathwayPurine Nucleoside MetabolismAdenosine Signaling PathwayEctonucleotidase Pathway
02
Mechanism of action
Modulation of adenosine receptor signaling; inhibition of adenosine metabolizing enzymes; altering extracellular adenosine concentration; interfering with purine metabolism.
03
Biological functions
Energy transferSignal transductionImmune modulationRegulation of cardiac functionRegulation of neurotransmissionRegulation of vascular tonePurine metabolism
04
Disease associations
CancerAutoimmune diseasesCardiovascular diseasesNeurological disordersInflammation
05
Safety considerations
Non-selective receptor activation leading to off-target effectsImmunosuppressionCardiovascular side effectsNeurotoxicityDevelopment of resistance
06
Interacting drugs
Adenosine analogs
7 more in the full profile.
07
Biomarkers
Adenosine levelsCD39 expressionCD73 expressionADA activityAdenosine receptor expression levelsInosine levelsHypoxanthine levels
Beyond the preview
Go deeper on Adenosine Metabolic Pathway (AMP).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Adenosine Metabolic Pathway (AMP).