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Target intelligence / Profile preview
Adenosine monophosphate–activated protein kinase (AMPK)
- Target
- AMPK
- Molecular classification
- Serine/threonine kinase, Enzyme
01
Overview
Adenosine monophosphate–activated protein kinase (AMPK) is a highly conserved serine/threonine kinase that functions as a central regulator of cellular and whole-body energy homeostasis. It acts as an energy sensor, becoming activated in response to stresses that deplete cellular ATP supplies. When activated, AMPK shifts metabolism toward processes that generate ATP while inhibiting those that consume it. Dysregulation of AMPK has been implicated in several diseases including type II diabetes mellitus, obesity, and cancer, making it an attractive therapeutic target for metabolic disorders.
- Other names
- 5' adenosine monophosphate–activated protein kinase
02
Mechanism of action
Stimulation of AMPK activity
03
Biological functions
Energy sensingRegulation of cellular energy homeostasisRegulation of whole-body energy homeostasisStimulates catabolic pathwaysInhibits anabolic processesGlucose uptakeFatty acid oxidationAutophagy
04
Disease associations
Type II diabetes mellitusObesityCancerMetabolic disordersAging
05
Interacting drugs
Metformin
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