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Target intelligence / Profile preview
Adenosine Monophosphate–Activated Protein Kinase Pathway (AMPK pathway)
- Target
- AMPK pathway
- Molecular classification
- Signaling Pathway, Kinase Pathway
01
Overview
The Adenosine monophosphate–activated protein kinase (AMPK) pathway is a central regulator of cellular and whole-body energy homeostasis. AMPK is activated by increased AMP/ATP or ADP/ATP ratios, signaling low cellular energy. Activation of AMPK leads to the restoration of ATP levels by switching off anabolic pathways and switching on catabolic pathways. It is a heterotrimeric enzyme composed of α, β, and γ subunits. Dysregulation of AMPK activity contributes to metabolic syndrome components and it represents an attractive drug target for treating metabolic diseases.
- Other names
- AMPK
02
Mechanism of action
AMPK activation
03
Biological functions
Energy homeostasisGlucose uptake regulationFatty acid oxidation regulationInsulin secretion modulationATP production enhancementMetabolic regulation
04
Disease associations
Type 2 diabetes mellitusCardiovascular diseaseMetabolic syndrome
05
Interacting drugs
Metformin
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