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Target intelligence / Profile preview
Adenosine Receptor A1 Subtype (A1AR)
- Target
- A1AR
- Molecular classification
- G protein-coupled receptor, Receptor
01
Overview
The adenosine A1 receptor (A1AR) is a G protein-coupled receptor that uses adenosine as its endogenous ligand. It is widely distributed throughout the body, with high expression in the central nervous system and moderate expression in peripheral tissues such as the heart, kidney, and pancreas. A1AR activation inhibits neurotransmitter release, reduces heart rate and contractility, and reduces renal blood flow. It is a potential therapeutic target for cardiac arrhythmias, neuroprotection, and sleep disorders.
- Other names
- ADORA1RDC7A1R
02
Mechanism of action
Gi/o protein activation, inhibition of adenylate cyclase, decreased cAMP levels, activation of phospholipase C, arachidonic acid production, modulation of ion channels
03
Biological functions
Signal transductionNeurotransmitter release inhibitionCardiac function modulationRenal blood flow regulationSleep promotion
04
Disease associations
Cardiac arrhythmiasBradycardiaIschemic eventsStrokeCardiac arrestSleep disordersAnxiety
05
Safety considerations
Potential cardiac effects (arrhythmias, bradycardia)Altered pain perception
06
Interacting drugs
Adenosine
3 more in the full profile.
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