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Target intelligence / Profile preview
Adenosine Receptor A3 (A3AR)
- Target
- A3AR
- Molecular classification
- G Protein-Coupled Receptor, Receptor
01
Overview
The adenosine A3 receptor (A3AR), also known as ADORA3, is a G protein-coupled receptor (GPCR) that binds adenosine. Activation leads to inhibition of adenylate cyclase and activation of phospholipase pathways. It is implicated in cardioprotection, immunomodulation, and neuroprotection/neurodegeneration. Overexpression in inflammatory and cancer cells makes it a target for anti-inflammatory and anticancer therapies. Clinical trials are ongoing with selective agonists for rheumatoid arthritis, and antagonists show potential for asthma treatment.
- Other names
- ADORA3
02
Mechanism of action
Gi/Gq protein coupling leading to inhibition of adenylate cyclase, activation of phospholipase Cβ (PLCβ), phospholipase D (PLD), PI3Kγ pathways, raising cytosolic Ca²⁺ concentration and activating PKC/ERK MAP kinases
03
Biological functions
Signal transductionImmunomodulationCardioprotectionNeuroprotectionNeurodegenerationRegulation of adenylate cyclase activityPhospholipase Cβ activationPhospholipase D activationPI3Kγ pathway activation
04
Disease associations
Cardiovascular diseaseInflammationCancerRheumatoid arthritisAsthma
05
Interacting drugs
CF101/Piclidenoson
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