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Adenosine Reuptake Transporter
- Molecular classification
- Transporter, Solute Carrier Superfamily, ENT (Equilibrative Nucleoside Transporter), CNT (Concentrative Nucleoside Transporter)
01
Overview
The adenosine reuptake transporter is a group of membrane transporters responsible for the cellular uptake of adenosine. These transporters, primarily belonging to the ENT (SLC29) and CNT (SLC28) families, regulate extracellular adenosine concentrations, thereby influencing purinergic signaling. They are involved in various physiological processes including neurotransmission, cardiovascular function, and immune responses, and their dysregulation can contribute to diseases such as cardiovascular disorders, neurological conditions, and cancer.
- Other names
- Equilibrative Nucleoside Transporters (ENTs)Concentrative Nucleoside Transporters (CNTs)SLC29 familySLC28 familyhENT1hENT2hENT3hENT4hCNT1hCNT2hCNT3
02
Mechanism of action
Inhibition of adenosine reuptake
03
Biological functions
Adenosine transportRegulation of extracellular adenosine concentrationModulation of purinergic signalingHomeostasisNeurotransmissionCardiovascular functionImmune responseTissue protection
04
Disease associations
Cardiovascular diseasesNeurological disordersCancer
05
Interacting drugs
Dipyridamole
2 more in the full profile.
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