Adenosine triphosphate–Tosyl-L-arginine methyl ester ternary complex (ATP–TAME–ATP)

The Adenosine triphosphate–Tosyl-L-arginine methyl ester (ATP–TAME) ternary complex is a supramolecular chemical assembly formed through non-covalent interactions between ATP and the synthetic arginine derivative TAME. This complex is primarily studied in the context of physical chemistry and molecular recognition to model how arginine residues in proteins interact with the phosphate and adenine moieties of ATP (Galan et al., J. Am. Chem. Soc.). The interaction typically involves electrostatic attraction and bidentate hydrogen bonding between the guanidinium group of TAME and the polyphosphate chain of ATP, alongside potential pi-stacking interactions. As noted in the target name, this is a non-therapeutic interaction, meaning it is a laboratory-observed chemical phenomenon rather than a biological pathway or receptor involved in disease. Consequently, it does not serve as a target for pharmacological intervention, and there are no drugs or clinical applications associated with it.

Other names

ATP-TAME complexTAME-ATP2 complexTosyl-L-arginine methyl ester-ATP interaction

Not applicable