Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Adenosylmethionine decarboxylase 1 (AMD1)
- Target
- AMD1
- Molecular classification
- Enzyme, Polyamine biosynthesis enzyme, Pyruvoyl-dependent amino acid decarboxylase
01
Overview
Adenosylmethionine decarboxylase 1 (AMD1) is an essential enzyme in the biosynthesis of polyamines, catalyzing the decarboxylation of S-adenosylmethionine to produce S-adenosylmethioninamine. This reaction provides the n-propylamine group for the synthesis of spermidine and spermine from putrescine, making AMD1 a critical regulator of cellular polyamine levels. Polyamines are vital for cell growth, proliferation, and survival as they are involved in DNA, RNA, and protein synthesis. AMD1 is unique among decarboxylases in using a covalently bound pyruvate residue as a cofactor. Dysregulation of AMD1 activity is implicated in cancer, developmental disorders, and other diseases, and it is considered a validated therapeutic target in oncology due to its role in promoting tumor cell growth.
- Other names
- S-adenosylmethionine decarboxylase proenzymeS-adenosylmethionine decarboxylase alpha chainS-adenosylmethionine decarboxylase beta chainAMDAdoMetDCSAMDCADOMETDC
02
Mechanism of action
Inhibition of polyamine biosynthesis: Drug inhibition leads to decreased synthesis of spermidine and spermine, affecting cell proliferation and survival
03
Biological functions
Polyamine biosynthesisMaintenance and self-renewal of embryonic stem cellsRegulation of cellular proliferationDNA, RNA, and protein synthesis
04
Disease associations
Cancer (polyamine pathway implicated in tumor promotion and cellular proliferation)Developmental and epileptic encephalopathyLeukemia (promotes leukemic stem cell maintenance and chronic myeloid leukemic growth)Sleeping sickness
05
Safety considerations
Risk of off-target effects due to widespread role of polyamines in normal cell functionPotential impact on stem cell renewal and development
06
Interacting drugs
Specific AMD1 inhibitors (such as SAM486A), though no common marketed drugs are detailed in these results
07
Biomarkers
Elevated polyamine levels (spermidine, spermine) may serve as biomarkers for cancer or stem cell proliferation
Beyond the preview
Go deeper on Adenosylmethionine decarboxylase 1 (AMD1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Adenosylmethionine decarboxylase 1 (AMD1).