Target intelligence / Profile preview

Adenovirus (AdV)

Target: AdV
Molecular classification: Virus, DNA Virus

Overview

Adenoviruses are a group of medium-sized, nonenveloped viruses with an icosahedral capsid structure that contain a double-stranded DNA genome. They are common pathogens in both humans and animals, capable of causing a wide range of illnesses, most frequently mild respiratory infections but also conjunctivitis, gastroenteritis, and other conditions. Adenoviruses are also used as vectors in gene therapy due to their ability to efficiently deliver genetic material without integrating it into host genomes.

Biological functions

Viral replicationHost cell infectionGene delivery (in gene therapy applications)

Disease associations

Respiratory tract infectionsConjunctivitisGastroenteritisBladder inflammation/infectionNeurologic disease

Safety considerations

Potential for severe infections in immunocompromised individualsRisk of off-target effects in gene therapy applicationsDevelopment of neutralizing antibodies against the viral vector

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