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Target intelligence / Profile preview
Adenovirus Antigen-Specific Cytotoxic T Lymphocyte (Adenovirus-specific CTL)
- Target
- Adenovirus-specific CTL
- Molecular classification
- T cell, Cytotoxic T lymphocyte (CTL), CD8+ T cell
01
Overview
Adenovirus antigen-specific cytotoxic T lymphocytes (CTLs) are a subset of CD8+ T cells that recognize and kill cells infected with adenoviruses by detecting viral peptides presented on MHC class I molecules. These CTLs play a crucial role in the immune response to adenoviral infections, particularly in immunocompromised individuals or following stem cell transplantation. They function by recognizing infected cells via their T cell receptor, releasing cytotoxic granules (perforin/granzymes), expressing Fas ligand, and secreting cytokines like IFN-gamma.
- Other names
- Adenovirus-specific CD8+ T cellAdenovirus CTLAd-specific CTL
02
Mechanism of action
Not applicable, cell-based therapy.
03
Biological functions
Cell-mediated cytotoxicityAntiviral immunitySecretion of cytokinesTarget cell killingImmune response
04
Disease associations
Viral infection (Adenovirus)ImmunodeficiencyPost-transplant complications
05
Safety considerations
Graft-versus-host disease (GVHD) (in allogeneic settings)Cytokine release syndromeOff-target effectsLimited persistence
06
Biomarkers
Frequency of adenovirus-specific CTLsExpression of activation markers (e.g., CD69)IFN-gamma production upon antigen stimulation
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