Target intelligence / Profile preview

Adenovirus Death Protein (ADP)

Target: ADP
Molecular classification: Membrane glycoprotein, Viral protein

Overview

The Adenovirus Death Protein (ADP), also known as E3-11.6K, is a small membrane glycoprotein encoded by the E3 region of adenoviruses. ADP is expressed at high levels during the very late phase of lytic adenoviral infection and plays a critical role in mediating efficient cell lysis and release of progeny virus particles from infected cells. It is also utilized in oncolytic virotherapy to enhance tumor-killing activity.

Other names: E3-11.6K

Mechanism of action

ADP promotes cell lysis, leading to the release of viral particles. In oncolytic virotherapy, ADP overexpression enhances tumor cell death.

Biological functions

Cell lysisVirion releaseRegulation of cell death

Disease associations

InfectionCancer (in the context of oncolytic virotherapy)

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