Adenovirus peptide-major histocompatibility complex

The Adenovirus peptide-MHC complex is a molecular entity comprising a peptide fragment derived from adenovirus proteins bound to the major histocompatibility complex (MHC), typically class I (such as HLA-A2 in humans or H-2Db in mice)[7]. These complexes are displayed on the surface of infected cells and are essential for recognition by cytotoxic T lymphocytes (CD8+ T cells), facilitating immune elimination of the virus[1][2][3][7]. Adenoviruses have evolved mechanisms, such as the E3-19K protein, to bind MHC class I molecules within the endoplasmic reticulum and inhibit their trafficking and phosphorylation, reducing immune detection[4][5]. Structural studies reveal that the interaction between adenovirus proteins and MHC molecules is highly specific, involving conserved domains within the MHC that serve as receptors for viral components[5][6][7].

Other names

Adenovirus peptide–MHC complexAdenovirus MHC complexAdenoviral antigen-MHC complexViral peptide-MHC complex

T-cell activation: Drugs or biologics can modulate presentation of adenovirus peptides by MHC to activate or suppress T-cell responses. Immune checkpoint modulation: Interventions may indirectly affect peptide-MHC presentation or recognition.