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Target intelligence / Profile preview
Adenovirus Serotype 4 (Ad4)
- Target
- Ad4
- Molecular classification
- Virus, Adenoviridae, Mastadenovirus (Human adenovirus), Aviadenovirus (Fowl adenovirus)
01
Overview
Adenovirus serotype 4 (Ad4) is a non-enveloped DNA virus belonging to the Adenoviridae family. It infects epithelial tissues and can cause acute respiratory disease in humans, particularly in military recruits. In poultry, FAdV-4 causes hydropericardium-hepatitis syndrome. Ad4 is used as a vector in gene therapy and vaccine development, leveraging its immunogenicity, but pre-existing immunity and potential safety concerns need to be considered.
- Other names
- Human adenovirus serotype 4Fowl adenovirus serotype 4FAdV-4
02
Mechanism of action
N/A
03
Biological functions
Viral replicationCell entryImmune evasionGene deliveryVaccine platform
04
Disease associations
Acute respiratory diseaseHydropericardium-hepatitis syndrome (poultry)Infection
05
Safety considerations
Pre-existing immunity limits efficacy of Ad4-based vectorsPotential for immunosuppressionRisk of off-target effects in gene therapy applications
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