Adenylyl Cyclase Type 1 (AC1)

Adenylyl Cyclase Type 1 (AC1) is an enzyme that catalyzes the conversion of ATP to cAMP, a key second messenger in cellular signaling pathways. It is specifically activated by calcium ions through calmodulin binding, making it a calmodulin-sensitive adenylyl cyclase. AC1 plays critical roles in the central nervous system, including regulation of neural circuit patterning, involvement in memory acquisition and learning, and modulation of circadian rhythm-related functions. Disruption of AC1 leads to defects in neural pattern formation. Pharmacologically targeting AC1 has shown promise as a novel analgesic strategy.

Other names

Adenylate cyclase type IAdenylate cyclase type 1Ca(2+)/calmodulin-activated adenylyl cyclaseATP pyrophosphate lyase 1ADCYI

AC1 catalyzes the conversion of ATP to cAMP, a second messenger involved in various cellular processes. Targeting AC1 can modulate cAMP levels and downstream signaling pathways.