Adenylate cyclase type 10 (ADCY10)

Adenylate cyclase type 10 (ADCY10) encodes a soluble adenylyl cyclase, a cytoplasmic enzyme responsible for catalyzing the conversion of ATP to cyclic AMP (cAMP), a ubiquitous second messenger involved in intracellular signaling. Unlike transmembrane adenylyl cyclases, ADCY10 is regulated by intracellular bicarbonate and is not controlled by G protein or forskolin. It plays critical roles in sperm function (including maturation, motility, and capacitation), pH regulation in renal and epididymal tissues, ciliary movement, and localized cAMP signaling within various cellular compartments (cytosol, nucleus, mitochondria). Mutations in ADCY10 are associated with male infertility and absorptive hypercalciuria. There are currently no approved therapeutic agents targeting ADCY10, but research continues into its physiological relevance and potential as a drug target.

Other names

Adenylate cyclase 10, solubleAdenylate cyclase homologSoluble adenylyl cyclasesACSACSacySACIhsACHCA2HEL-S-7aGerm cell soluble adenylyl cyclaseTesticular soluble adenylyl cyclase3',5'-cyclic AMP synthetaseATP pyrophosphate-lyaseEpididymis secretory sperm binding protein Li 7aAH-related proteinHypercalciuria, absorptive, 2

Not applicable for clinical drugs; for research inhibitors, mechanism is typically competitive inhibition of the catalytic domain, preventing cAMP formation from ATP