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Target intelligence / Profile preview
Adenylate cyclase type 6 (ADCY6)
- Target
- ADCY6
- Molecular classification
- Enzyme, Adenylyl Cyclase
01
Overview
Adenylate cyclase 6 (ADCY6) is a membrane-associated enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic adenosine monophosphate (cAMP). cAMP is a crucial second messenger involved in transducing signals from G protein-coupled receptors (GPCRs) and regulates numerous physiological processes including cardiac contractility, vascular tone, and cellular responses to hormones and neurotransmitters. ADCY6 is regulated by G proteins, calcium ions, nitric oxide, and protein kinases, and its dysregulation is associated with various diseases, including lethal congenital contracture syndrome, neuropathy-arthrogryposis syndrome and cardiovascular diseases.
02
Mechanism of action
Catalyzes the conversion of ATP to cAMP
03
Biological functions
Signal transductioncAMP synthesisRegulation of cardiac contractilityRegulation of vascular tone
04
Disease associations
Lethal Congenital Contracture Syndrome type 8Hypomyelination Neuropathy-Arthrogryposis SyndromeCardiovascular diseaseCancer
05
Interacting drugs
Forskolin
1 more in the full profile.
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